Trethera Doses First Patient in Landmark Clinical Trial for the Treatment of Solid Tumors With First-In-Class Drug TRE-515

Los Angeles, October 15, 2021 — Trethera Corporation (“Trethera”), a biopharmaceutical company committed to developing novel drugs targeting nucleotide metabolism for the treatment of cancer and autoimmune diseases, announced that the first patient has been treated with TRE-515, a first-in-class inhibitor of deoxycytidine kinase (dCK). Trethera’s multi-site Phase 1 study will evaluate TRE-515 monotherapy in up to 36 patients with various solid tumors.

“I am thrilled to announce the world’s first clinical stage dCK inhibitor, TRE-515” said Dr. Ken Schultz, Trethera Chairman and CEO. “This study will assess the safety and tolerability of TRE-515, as well as utilize multiple biomarkers to measure target engagement, a valuable tool for predicting antitumor activity in the clinic. We look forward to sharing future updates as the clinical trial progresses.”

“The first patient dosed marks a significant milestone toward delivering on the promise and potential of an exciting new clinical treatment strategy targeting dCK,” said Dr. Michael Shepard, Lasker Laureate and member of the Trethera Scientific Advisory Board. “TRE-515 is a one-of-a-kind small molecule inhibitor that has the potential to durably treat devastating diseases such as cancer and multiple sclerosis.”

Trethera’s US-based clinical trial evaluates the safety and tolerability of TRE-515 in patients with various solid tumor malignancies. A common characteristic of solid tumors is the rapid cellular DNA replication necessary to enable accelerated malignant growth. TRE-515 is an orally delivered therapeutic engineered to inhibit dCK, the key enzyme in a nucleotide metabolism pathway shown to be overexpressed in cancer cells. By targeting dCK, scientists hope to selectively and effectively deprive cancer cells of a needed additional source of nucleotides, thereby blocking DNA replication and halting tumor progression.

“For years, Trethera has had an unwavering commitment to advancing nucleotide metabolism treatments,” said Dr. Caius Radu, co-founder and primary inventor. “With the first patient treated in this historic clinical trial, we mark a significant step in advancing the TRE-515 clinical program and move closer to our goal of developing a game-changing medicine for patients with cancer and autoimmune diseases.”

“TRE-515 is intelligently designed and on target, knocking out dCK, which could be a key to stopping the growth of certain tumors or modulating select autoimmune diseases,” said Dr. Owen Witte, co-founder and Scientific Advisory Board member. “Advancing a first-in-class drug from bench to bedside represents a remarkable scientific achievement.”

About Trethera

Trethera is a clinical stage privately held biopharmaceutical company dedicated to pioneering the development of novel treatments for autoimmune diseases and cancers. Founded by prominent UCLA scientists, Trethera is led by experienced management and board members. Trethera’s innovative approach to targeting nucleotide metabolism led to the development of TRE-515, an orally taken capsule designated by the FDA as an Orphan Drug. TRE-515 is a first-in-class clinical stage drug that inhibits deoxycytidine kinase (dCK), the rate-limiting enzyme in the nucleoside salvage pathway, one of two biosynthetic pathways that generate DNA precursors. It is believed that some forms of cancer may be preferentially dependent on the salvage pathway to support tumor growth. Certain autoimmune diseases might respond to TRE-515 treatment. Trethera is developing TRE-515 for use as a monotherapy or in combination, to precisely target a metabolic vulnerability of cancer cells or autoimmune diseases that will transform outcomes for patients.

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Note on Forward-Looking Statements

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