Trethera Publications

Gloved hand of a scientist in a lab writing on a digital stilus with a digital pen.Blue DNA illustrationPhoto of a series of test tubes.Scientific microscope with visual representation of DNA helix

Targeting Deoxycytidine Kinase Improves Symptoms in Mouse Models of Multiple Sclerosis

January 16, 2023

This study in EAE mouse models of MS shows that TRE‑515, a dCK inhibitor, reduces disease severity by limiting lymphocyte proliferation and CNS infiltration—without impacting innate or naive immune cells. Indicates dCK's key role in disease progression.

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18F-FAC PET Visualizes Brain-Infiltrating Leukocytes in a Mouse Model of Multiple Sclerosis

May 1, 2020

This study demonstrates that 18F-FAC PET crosses the blood–brain barrier and accumulates in brain-infiltrating leukocytes in EAE mice, and that it can monitor therapeutic effects—like fingolimod treatment—on immune cell infiltration in the CNS.

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Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

October 23, 2014

Using crystal structures of dCK bound to lead compounds, researchers enhanced inhibitor design to isolate an R‑isomer with >60-fold greater affinity and improved metabolic stability—creating a promising candidate for leukemia and broader cancer treatment.

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Deoxycytidine Kinase Augments ATM-Mediated DNA Repair and Contributes to Radiation Resistance

August 7, 2014

This study elucidates how ATM-mediated phosphorylation of deoxycytidine kinase (dCK) enhances DNA repair by increasing dCTP pools post-radiation. Loss of dCK increases radiosensitivity, suggesting its inhibition could serve as a radiosensitization strategy.

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Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

November 12, 2012

In a mouse model, deoxycytidine kinase (dCK) deficiency caused dCTP depletion, replication stress, and hematopoietic defects that were nearly reversed in dCK/TK1 double knockouts. This uncovers mechanisms of nucleotide regulation and therapeutic potential.

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