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Publications

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

19th November 2012/in Publications /by admin

Abstract: Nucleotide deficiency causes replication stress (RS) and DNA damage in dividing cells. How nucleotide metabolism is regulated in vivo to prevent these deleterious effects remains unknown. In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and thymidine kinase (TK1). We show […]

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https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png 0 0 admin https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png admin2012-11-19 12:13:462017-03-06 12:14:15Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

Novel Positron Emission Tomography Probes Specific for Deoxycytidine Kinase

22nd June 2011/in Publications /by admin

Abstract: Deoxycytidine kinase (dCK) is a rate-limiting enzyme in the deoxyribonucleoside salvage pathway and a critical determinant of therapeutic activity for several nucleoside analog pro-drugs. We have previously reported the development of 18F-FAC, (1-(2′-deoxy-2′-18F-fluoro-β-D-arabinofuranosyl) cytosine), a new probe for PET imaging of dCK activity in immune disorders and certain cancers. The objective of the current […]

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https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png 0 0 admin https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png admin2011-06-22 12:15:082017-03-06 12:15:41Novel Positron Emission Tomography Probes Specific for Deoxycytidine Kinase

Requirement for deoxycytidine kinase in T and B lymphocyte development

31st December 2009/in Publications /by admin

Abstract: Deoxycytidine kinase (dCK) is a rate-limiting enzyme in deoxyribonucleoside salvage, a metabolic pathway that recycles products of DNA degradation. dCK phosphorylates and therefore activates nucleoside analog prodrugs frequently used in cancer, autoimmunity, and viral infections. In contrast to its well established therapeutic relevance, the biological function of dCK remains enigmatic. Highest levels of dCK […]

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https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png 0 0 admin https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png admin2009-12-31 12:15:512017-03-06 12:16:20Requirement for deoxycytidine kinase in T and B lymphocyte development

Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2′-deoxycytidine analog

3rd August 2009/in Publications /by admin

Abstract: Monitoring immune function using molecular imaging could significantly impact the diagnosis and treatment evaluation of immunological disorders and therapeutic immune responses. Positron Emission Tomography (PET) is a molecular imaging modality with applications in cancer and other diseases. PET studies of immune function have been limited by a lack of specialized probes. We identified [18F]FAC […]

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https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png 0 0 admin https://www.trethera.com/wp-content/uploads/2015/12/trethera_logo-wo.png admin2009-08-03 12:16:342017-03-06 12:17:04Molecular imaging of lymphoid organs and immune activation using positron emission tomography with a new 18F-labeled 2′-deoxycytidine analog
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